A multidisciplinary treatment strategy that includes high-dose chemotherapy for metastatic retinoblastoma without CNS involvement
نویسندگان
چکیده
منابع مشابه
High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: a randomized trial.
PURPOSE The aims of this study were to compare in a randomized trial the results of high-dose versus conventional-dose chemotherapy as first-line treatment for metastatic breast cancer. The comparison included complete response (CR) rate, duration of response, and duration of survival. PATIENTS AND METHODS Ninety patients were entered onto a study to compare two cycles of high-dose cyclophosp...
متن کاملNeural Transplantation as a Strategy for Recovery of CNS Functions
Transplants of neural tissue have been used for nearly 100 years in order to clarify the mechanisms that underlie development and regeneration of the nervous system. With reports from Sweden and Mexico that autografts of adrenal medulla produce at least transient and perhaps dramatic improvement in patients severly disabled by Parkinson's disease, the techniques of neural transplantation have ...
متن کاملThe UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy and Response Directed High Dose Myeloablative Chemotherapy or Maintenance Chemotherapy (Milan Strategy).
BACKGROUND Historically, the 5-year overall survival (OS) for metastatic medulloblastoma (MMB) was less than 40%. The strategy of post-operative induction chemotherapy (IC) followed by hyperfractionated accelerated radiotherapy (HART) and response directed high dose chemotherapy (HDC) was reported in a single center study to improve 5-year OS to 73%. We report outcomes of this strategy in UK. ...
متن کاملComment on: The UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy, and Response Directed High-Dose Myeloablative Chemotherapy or Maintenance Chemotherapy (Milan Strategy).
To the Editor: We read with both interest and concern the paper by Vivekanandan published in this journal.[1] While the lower results for metastatic medulloblastoma compared to those originally reported by Gandola [2] were already known,[3] we were quite disappointed by some comments on our experience, and the lack of important, internationally recently shared aspects. First, it is questionable...
متن کاملReply to Comment on: The UK Experience of a Treatment Strategy for Pediatric Metastatic Medulloblastoma Comprising Intensive Induction Chemotherapy, Hyperfractionated Accelerated Radiotherapy, and Response-Directed High-Dose Myeloablative Chemotherapy or Maintenance Chemotherapy (Milan Strategy).
To the Editor: We thank Massimino and colleagues [1] for their comments on our paper.[2] Our study was a retrospective audit of survival, toxicity, and deliverability of this regimen in 14 UK centers. It was not our intention to criticize the Milan group’s work.[3] However, it is essential to monitor outcomes when introducing new treatments, especially when these are of high intensity and in hi...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2005
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1704882